Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy.

Li, Dongmei; Zheng, Ji; Wang, Mingyang; Feng, Lu; Liu, Yanyong; Yang, Nan; Zuo, Pingping

Li, Dongmei; Zheng, Ji; Wang, Mingyang; Feng, Lu; Liu, Yanyong; Yang, Nan; Zuo, Pingping.

Afiliação

Li D; Department of Pharmacology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Zheng J; Department of Pharmacology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Wang M; Department of Pharmacology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Feng L; Department of Pharmacology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Liu Y; Department of Pharmacology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China. Electronic address: liuyanyong@126.com.
Yang N; Department of Pharmacology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China. Electronic address: yangnanbeijing@126.com.
Zuo P; Department of Pharmacology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.

J Ethnopharmacol ; 186: 181-188, 2016 Jun 20.

Article em En | MEDLINE | ID: mdl-27063986

Assuntos

Antidepressivos/farmacologia; Medicamentos de Ervas Chinesas/farmacologia; Desamparo Aprendido; Mitofagia/efeitos dos fármacos; Receptores de GABA/metabolismo; Animais; Medicamentos de Ervas Chinesas/administração & dosagem; Fluoxetina/farmacologia; Regulação da Expressão Gênica/efeitos dos fármacos; Masculino; Mesencéfalo/efeitos dos fármacos; Mesencéfalo/metabolismo; Camundongos; Camundongos Endogâmicos ICR; Distribuição Aleatória; Receptores de GABA/genética; Inibidores Seletivos de Recaptação de Serotonina/farmacologia; Transdução de Sinais/fisiologia

Palavras-chave

18kDa translocator protein (TSPO); CMC-Na (PubChem CID: 6328154); Depression; EDTA (PubChem CID: 6049); Fluoxetine (PubChem CID: 62857); H(2)O(2) (PubChem CID: 784); Learned Helplessness; Paraformaldehyde (PubChem CID: 62081); Pentobarbital sodium (PubChem CID: 23676152); Phosphate buffered saline (PubChem CID: 24978514); SDS (PubChem CID: 3423265); Sucrose (PubChem CID: 5988); Tris (PubChem CID: 6503); Wuling powder, Mitophagy

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Medicamentos de Ervas Chinesas / Receptores de GABA / Mitofagia / Desamparo Aprendido / Antidepressivos Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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