Vitamin D and/or calcium deficient diets may differentially affect muscle fiber neuromuscular junction innervation.
Muscle Nerve
; 54(6): 1120-1132, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27074419
ABSTRACT
INTRODUCTION:
There is evidence that supports a role for Vitamin D (Vit. D) in muscle. The exact mechanism by which Vit. D deficiency impairs muscle strength and function is not clear.METHODS:
Three-week-old mice were fed diets with varied combinations of Vit. D and Ca2+ deficiency. Behavioral testing, genomic and protein analysis, and muscle histology were performed with a focus on neuromuscular junction (NMJ) -related genes.RESULTS:
Vit. D and Ca2+ deficient mice performed more poorly on given behavioral tasks than animals with Vit. D deficiency alone. Genomic and protein analysis of the soleus and tibialis anterior muscles revealed changes in several Vit. D metabolic, NMJ-related, and protein chaperoning and refolding genes.CONCLUSIONS:
These data suggest that detrimental effects of a Vit. D deficient or a Vit. D and Ca2+ deficient diet may be a result of differential alterations in the structure and function of the NMJ and a lack of a sustained stress response in muscles. Muscle Nerve 54 1120-1132, 2016.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Ácido Ascórbico
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Regulação da Expressão Gênica
/
Fibras Musculares Esqueléticas
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Dieta
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Membro Posterior
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Junção Neuromuscular
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Revista:
Muscle Nerve
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos