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Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN).
Wang, Youxin; Di, Hongxia; Chen, Feifei; Xu, Yong; Xiao, Qiang; Wang, Xuehai; Wei, Hanwen; Lu, Yanli; Zhang, Lingling; Zhu, Jin; Lan, Lefu; Li, Jian.
Afiliação
  • Wang Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China.
  • Di H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China.
  • Chen F; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China.
  • Xu Y; Hubei Bio-pharmaceutical Industrial Technological Institute, Inc. , Wuhan 430075, China.
  • Xiao Q; Hubei Bio-pharmaceutical Industrial Technological Institute, Inc. , Wuhan 430075, China.
  • Wang X; Humanwell Healthcare (Group) Co., Ltd. , Wuhan 430075, China.
  • Wei H; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China.
  • Lu Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China.
  • Zhang L; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China.
  • Zhu J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China.
  • Lan L; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China.
  • Li J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China.
J Med Chem ; 59(10): 4831-48, 2016 05 26.
Article em En | MEDLINE | ID: mdl-27139780

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Plantas_medicinales Assunto principal: Oxirredutases / Infecções Estafilocócicas / Alcanos / Inibidores Enzimáticos / Staphylococcus aureus Resistente à Meticilina / Descoberta de Drogas / Antibacterianos Idioma: En Revista: J Med Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Plantas_medicinales Assunto principal: Oxirredutases / Infecções Estafilocócicas / Alcanos / Inibidores Enzimáticos / Staphylococcus aureus Resistente à Meticilina / Descoberta de Drogas / Antibacterianos Idioma: En Revista: J Med Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China