Prevention of H2O2 Induced Oxidative Damages of Rat Testis by Thymus algeriensis.
Biomed Environ Sci
; 29(4): 275-85, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-27241738
ABSTRACT
OBJECTIVE:
We evaluate the effects of Thymus algeriensis (TEO) against hydrogen peroxide (H2O2) toxicity on body and testis weight, testis sperm count, testis lipid peroxidation, and antioxidant enzyme activities in rats.METHODS:
Rats were treated with low (LD) and high dose (HD) of H2O2 (0.1 and 1 mmol/L) in the presence or absence of TEO (150 mg/kg).RESULTS:
The results exhibited a significant decrease in body weight and testis weight, in total sperm number decrease (P<0.05), sperm motility and percentage of sperm viability, leading to complete arrest, in sperm flagellar beat frequency by the gavage of 1 mmol/L H2O2 compared to controls. The administration of H2O2 resulted in a significant reduction in testis GSH, GPx, CAT, SOD, and GST activity and significant increase (P<0.05) in MDA concentration compared with the untreated control animals. TEO pre-treatment protected testis from the H2O2 generated oxidative stress. These results were confirmed by histological architecture examinations.CONCLUSION:
H2O2 has the ability to alter the sperm function, characteristics and development of testis. However, TEO is an efficient natural agent, which can prevent the testis from H2O2-induced oxidative damage in rats.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Testículo
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Extratos Vegetais
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Estresse Oxidativo
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Thymus (Planta)
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Peróxido de Hidrogênio
Idioma:
En
Revista:
Biomed Environ Sci
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos