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Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics.
Yu, Ru-Jian; Liu, Hai-Bin; Yu, Yang; Liang, Lu; Xu, Rui; Liang, Chun; Tang, Jin-Shan; Yao, Xin-Sheng.
Afiliação
  • Yu RJ; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
  • Liu HB; Division of Life Science, Center for Cancer Research, State Key Lab for Molecular Neural Science, Bioengineering Graduate Program, Hong Kong University of Science and Technology, Hong Kong, PR China; Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd, Guangzhou, PR China.
  • Yu Y; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
  • Liang L; Division of Life Science, Center for Cancer Research, State Key Lab for Molecular Neural Science, Bioengineering Graduate Program, Hong Kong University of Science and Technology, Hong Kong, PR China.
  • Xu R; Division of Life Science, Center for Cancer Research, State Key Lab for Molecular Neural Science, Bioengineering Graduate Program, Hong Kong University of Science and Technology, Hong Kong, PR China.
  • Liang C; Division of Life Science, Center for Cancer Research, State Key Lab for Molecular Neural Science, Bioengineering Graduate Program, Hong Kong University of Science and Technology, Hong Kong, PR China; Intelgen Limited, Hong Kong-Guangzhou-Foshan, PR China. Electronic address: bccliang@ust.hk.
  • Tang JS; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: gztangjinshan@126.com.
  • Yao XS; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: tyaoxs@jnu.edu.cn.
Fitoterapia ; 112: 175-82, 2016 Jul.
Article em En | MEDLINE | ID: mdl-27242217
Phytochemical investigation of the stem of Urceola huaitingii resulted in the isolation of nine proanthocyanidins (1-9), including a new compound (9). Their chemical structures were determined by UV, (HR) ESI-MS, 1D-, 2D-NMR, and CD spectra in combination with chemical derivatization. Determination of the absolute configuration of proanthocyanidins were discussed, which suggested that positive Δε values at 245nm can be applied to determine the absolute configuration of them. In addition, anticancer activities of proanthocyanidins (1-9) and their synergistic anticancer effects in combination with chemotherapeutics were evaluated. The results showed that some proanthocyanidins, especially compound 7 possessing two doubly interflavonoid linkages, exhibited significant synergistic anticancer effects with some chemotherapeutics in multiple cancer cell lines.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caules de Planta / Apocynaceae / Proantocianidinas / Antineoplásicos Fitogênicos Idioma: En Revista: Fitoterapia Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caules de Planta / Apocynaceae / Proantocianidinas / Antineoplásicos Fitogênicos Idioma: En Revista: Fitoterapia Ano de publicação: 2016 Tipo de documento: Article