Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer.
Bioanalysis
; 8(13): 1325-36, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27277875
ABSTRACT
AIM:
Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results &methodology:
Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range.CONCLUSION:
Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espectrometria de Massas
/
Óleos de Plantas
/
Testes Respiratórios
/
Compostos Orgânicos Voláteis
/
Mentol
Idioma:
En
Revista:
Bioanalysis
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido