Calcium phosphate: a substitute for aluminum adjuvants?
Expert Rev Vaccines
; 16(3): 289-299, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-27690701
ABSTRACT
INTRODUCTION:
Calcium phosphate was used as an adjuvant in France in diphtheria, tetanus, pertussis and poliomyelitis vaccines. It was later completely substituted by alum salts in the late 80's, but it still remains as an approved adjuvant for the World Health Organization for human vaccination. Area covered Thus, calcium phosphate is now considered as one of the substances that could replace alum salts in vaccines. The aim of this paper is to draw a review of existing data on calcium phosphate as an adjuvant in order to bring out the strengths and weaknesses for its use on a large scale. Expert commentary Calcium phosphate is a compound naturally present in the organism, safe and already used in human vaccination. Beyond comparisons with the other adjuvants, calcium phosphate represents a good candidate to replace or to complete alum salts as a vaccine adjuvant.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfatos de Cálcio
/
Adjuvantes Imunológicos
/
Alumínio
Idioma:
En
Revista:
Expert Rev Vaccines
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
França