Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue.
Bull Exp Biol Med
; 161(5): 683-686, 2016 Sep.
Article
em En
| MEDLINE
| ID: mdl-27709383
ABSTRACT
Effectiveness of the granulocyte colony-stimulating factor immobilized by using electronbeam synthesis nanotechnology was investigated on the model of experimental testicular failure caused by the toxic effect on stem spermatogonia. Administration of the drug to experimental paclitaxel-treated animals increased the number of sources of the proliferative pool of spermatogenesis and its productivity. The effectiveness of immobilized granulocyte colony-stimulating factor was based on its ability to stimulate reparative regeneration of the spermatogenic tissue, which manifested in a decrease in spermatogenic layer maturity and increase in the number of microenvironment cells. Effectiveness of the immobilized form of the drug was superior to that of non-immobilized form.
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Base de dados:
MEDLINE
Assunto principal:
Espermatogônias
/
Fator Estimulador de Colônias de Granulócitos
/
Proteínas Imobilizadas
/
Infertilidade Masculina
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Federação Russa