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Chiral separation and absolute configurations of two pairs of racemic polyprenylated benzophenones from Hypericum sampsonii.
Tian, Wen-Jing; Qiu, Yu-Qin; Chen, Hai-Feng; Jin, Xiao-Jie; Yao, Xiao-Jun; Dai, Yi; Yao, Xin-Sheng.
Afiliação
  • Tian WJ; School of Pharmaceutical Science, Xiamen University, China; College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, China.
  • Qiu YQ; Institute of Traditional Chinese Medicine & Natural Products, Jinan University, China.
  • Chen HF; School of Pharmaceutical Science, Xiamen University, China.
  • Jin XJ; College of Chemistry and Chemical Engineering, Lanzhou University, China.
  • Yao XJ; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China; College of Chemistry and Chemical Engineering, Lanzhou University, China.
  • Dai Y; Institute of Traditional Chinese Medicine & Natural Products, Jinan University, China. Electronic address: daiyi1004@163.com.
  • Yao XS; Institute of Traditional Chinese Medicine & Natural Products, Jinan University, China; College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, China. Electronic address: tyaoxs@jnu.edu.cn.
Fitoterapia ; 116: 39-44, 2017 Jan.
Article em En | MEDLINE | ID: mdl-27818319
ABSTRACT
(±) Sampsonins A-B (1-2), two pairs of racemic polyprenylated benzophenones, were isolated from the aerial parts of Hypericum sampsonii and successfully separated by chiral HPLC column. Their structures were elucidated by spectroscopic analyses, X-ray diffraction analysis, and quantum chemical calculation of ECD method. Besides, the plausible biogenetic pathways of 1-2 were proposed, and all of them were evaluated for RXRα transcriptional-inhibitory activities and cytotoxicity against HeLa cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofenonas / Hypericum Idioma: En Revista: Fitoterapia Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofenonas / Hypericum Idioma: En Revista: Fitoterapia Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China