Chemical composition and evaluation of prolyl oligopeptidase and acetylcholinesterase inhibitory activities of Leonurus Sibiricus L. from Brazil.
Nat Prod Res
; 31(12): 1459-1463, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-27834099
ABSTRACT
Chemical investigation of the aerial parts of Leonurus sibiricus L. used in Brazilian folk medicine led to the identification of the following constituents the labdane-type diterpenoid leojaponin, the phytosterols ß-sitosterol and ß-sitosterol glucoside and the alkaloid leonurine. The crude extracts obtained from methanol and methanol/1% HCl and pure compounds isolated from L. sibirius were investigated as acetylcholinesterase (AChE) and prolyl oligopeptidase (POP) inhibitors. Extracts obtained by maceration were active against POP (53-58%), but showed weak activity against AChE. The isolated leojaponin and leonurine were evaluated as POP inhibitors.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetilcolinesterase
/
Serina Endopeptidases
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Extratos Vegetais
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Inibidores de Serina Proteinase
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Inibidores da Colinesterase
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Leonurus
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil