Anti-inflammatory effect of a fatty acid mixture with high ω-9:ω-6 ratio and low ω-6:ω-3 ratio on rats submitted to dental extraction.
Arch Oral Biol
; 74: 63-68, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27883909
ABSTRACT
OBJECTIVE:
To evaluate the anti-inflammatory effect of pretreatment for three days with a fatty acid mixture with high ω-9ω-6 ratio and low ω-6ω-3 ratio on rats submitted to dental extraction. MATERIAL ANDMETHODS:
Thirty-two male Wistar rats (270-310g) were randomly distributed in four groups (n=8/group) the sham control group and the negative control group received saline; the high omega-6/low omega-9 group received isolipid fatty acid with high ω-6ω-3 ratio and low ω-9ω-6 ratio; the high omega-3/low omega-6 group received fatty acid with low ω-6ω-3 ratio and high ω-9ω-6 ratio. Saline and oils were administered by gavage for 4days before exodontia and 3days after surgery, followed by euthanasia. Masseter edema was evaluated clinically and tissue samples were submitted to osteoclast count (H&E), myeloperoxidase assay, and western blotting (tumor necrosis factor-alpha and interleukin-1beta).RESULTS:
In the high omega-3/low omega-6 group, a significant decrease was observed in masseter edema (p<0.0001), myeloperoxidase (p<0.0001), osteoclasts (p=0.0001) and TNF-α expression (p<0.0001), but not in IL-1ß expression.CONCLUSION:
The ingestion of fatty acid with high ω-9ω-6 ratio and low ω-6ω-3 ratio significantly reduced inflammatory response in rats submitted to dental extraction.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Extração Dentária
/
Ácidos Graxos Ômega-3
/
Ácidos Graxos Ômega-6
/
Ácidos Graxos
/
Anti-Inflamatórios
Idioma:
En
Revista:
Arch Oral Biol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil