Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition.

Huang, Zhizhou; Zhou, Xueqiong; He, Yangfan; Ke, Xiangyu; Wen, Ying; Zou, Fei; Chen, Xuemei

Huang, Zhizhou; Zhou, Xueqiong; He, Yangfan; Ke, Xiangyu; Wen, Ying; Zou, Fei; Chen, Xuemei.

Afiliação

Huang Z; Department of Occupational Health and Medicine, School of Public Health, Southern Medical University, 1838 Guangzhou Road North, Guangzhou, 510515, China.
Zhou X; Department of Occupational Health and Medicine, School of Public Health, Southern Medical University, 1838 Guangzhou Road North, Guangzhou, 510515, China.
He Y; Department of Occupational Health and Medicine, School of Public Health, Southern Medical University, 1838 Guangzhou Road North, Guangzhou, 510515, China.
Ke X; Department of Occupational Health and Medicine, School of Public Health, Southern Medical University, 1838 Guangzhou Road North, Guangzhou, 510515, China.
Wen Y; Department of Occupational Health and Medicine, School of Public Health, Southern Medical University, 1838 Guangzhou Road North, Guangzhou, 510515, China.
Zou F; Department of Occupational Health and Medicine, School of Public Health, Southern Medical University, 1838 Guangzhou Road North, Guangzhou, 510515, China.
Chen X; Department of Occupational Health and Medicine, School of Public Health, Southern Medical University, 1838 Guangzhou Road North, Guangzhou, 510515, China.

Sci Rep ; 6: 38072, 2016 12 02.

Article em En | MEDLINE | ID: mdl-27909289

Assuntos

Benzoquinonas/farmacologia; Carcinoma Hepatocelular/tratamento farmacológico; Dano ao DNA/efeitos dos fármacos; Hipertermia Induzida/métodos; Lactamas Macrocíclicas/farmacologia; Neoplasias Hepáticas/tratamento farmacológico; Animais; Proteína Quinase CDC2/metabolismo; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patologia; Proteínas de Ciclo Celular/metabolismo; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Chaperoninas/metabolismo; Ciclina B1/metabolismo; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Proteínas de Choque Térmico HSP90/metabolismo; Células Hep G2; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patologia; Masculino; Camundongos Endogâmicos BALB C; Espécies Reativas de Oxigênio/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Benzoquinonas / Carcinoma Hepatocelular / Lactamas Macrocíclicas / Hipertermia Induzida / Neoplasias Hepáticas Idioma: En Revista: Sci Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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