Induction of apoptosis and DNA damage by 4-nonylphenol in African catfish (Clarias gariepinus) and the antioxidant role of Cydonia oblonga.
Ecotoxicol Environ Saf
; 139: 97-101, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28113117
ABSTRACT
In this study, we assessed the toxic effects of sub lethal concentration (0.1mgl-1) 4-nonylphenol (4-NP) on serum biochemical parameters, liver lipid peroxidation (LPO) and antioxidant enzymes of the African catfish Clarias gariepinus for 14 days and the ability of the quince leaf extract to alleviate the effects of (4-NP). Fish were categorized into four groups control, exposure to 0.1mgl-1 4-NP, exposure to 0.1mgl-1 4-NP with quince leaf extract (10ml/30L water), and exposure to 0.1mgl-1 4-NP with quince leaf extract (20ml/30L water). 4-NP exposure induced a significant (p<0.05) increase in the levels of glucose, AST, ALT, creatinine, urea, uric acid, cholesterol, and G6PDH as well as, the percentages of hepatic LPO level, DNA fragmentation, and apoptotic erythrocytes (p<0.05). A significant (p<0.05) decrease in alkaline phosphatase (ALP), total protein, albumin, globulin, total lipids, and LDH were also recorded. Liver enzyme activities (SOD, CAT and TAC) were increased. Addition of the quince leaf extract into the water was able to reinstate the alterations in biochemical parameters, antioxidant biomarkers, apoptotic level and hepatic DNA damage induced by 4-NP.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Poluentes Químicos da Água
/
Peixes-Gato
/
Extratos Vegetais
/
Apoptose
/
Rosaceae
/
Fragmentação do DNA
Idioma:
En
Revista:
Ecotoxicol Environ Saf
Ano de publicação:
2017
Tipo de documento:
Article