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Polyphenols rich Passiflora leschenaultii leaves modulating Farnesoid X Receptor and Pregnane X Receptor against paracetamol-induced hepatotoxicity in rats.
Shanmugam, Saravanan; Sivaraj, Dhivya; Dos Santos Lima, Bruno; Dos Passos Menezes, Paula; de Carvalho, Yasmim Maria Barbosa Gomes; de Souza Araújo, Adriano Antunes; Narain, Narendra; Serafini, Mairim Russo; Quintans Júnior, Lucindo José; Scotti, Luciana; Scotti, Marcus Tulius; Parimelazhagan, Thangaraj.
Afiliação
  • Shanmugam S; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil. Electronic address: saranflora04@gmail.com.
  • Sivaraj D; Bioprospecting laboratory, Department of Botany, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India.
  • Dos Santos Lima B; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
  • Dos Passos Menezes P; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
  • de Carvalho YMBG; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
  • de Souza Araújo AA; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil. Electronic address: adriasa2001@yahoo.com.br.
  • Narain N; Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
  • Serafini MR; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
  • Quintans Júnior LJ; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
  • Scotti L; Department of Chemistry, Federal University of Paraíba, Joao Pessoa, Paraíba, CEP, 58051900, Brazil.
  • Scotti MT; Department of Chemistry, Federal University of Paraíba, Joao Pessoa, Paraíba, CEP, 58051900, Brazil.
  • Parimelazhagan T; Bioprospecting laboratory, Department of Botany, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India. Electronic address: drparimel@gmail.com.
Biomed Pharmacother ; 88: 1114-1121, 2017 Apr.
Article em En | MEDLINE | ID: mdl-28192885
The hepatoprotective effect of P. leschenaultii. (DC) leaves was investigated in rats under paracetamol induced oxidative stress. Leaf acetone extract (200 and 400mg/kg) were administered daily via gavage for 14days before paracetamol (2000mg/kg, p.o.) treatment. After the experiment, the levels of serum biochemical parameters and enzymatic antioxidant levels were determined. Furthermore, liver tissues were analyzed histopathologically. Additionally, the molecular docking studies of the identified compounds against PXR and FXR proteins were also performed. The assessment revealed that the acetone extract significantly reduced the elevated levels of SGPT, SGOT and ALP in serum. Moreover, the enzymatic antioxidants such as SOD, CAT and LPO were also retained normally by the plant extract. From histopathological analysis, it was clearly evident that the cellular architecture of plant extract treated rat liver tissues were not affected by the paracetamol induction at the higher dose. The results of docking studies also revealed that the identified compounds showed steric interactions (between nonpolar atoms) with amino acid groups. Collectively, the present study suggests that P. leschenaultii leaves extract protects the liver from paracetamol induced hepatic damage.
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Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas / Plantas_medicinales Assunto principal: Receptores de Esteroides / Receptores Citoplasmáticos e Nucleares / Folhas de Planta / Passiflora / Polifenóis / Hepatopatias / Acetaminofen Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas / Plantas_medicinales Assunto principal: Receptores de Esteroides / Receptores Citoplasmáticos e Nucleares / Folhas de Planta / Passiflora / Polifenóis / Hepatopatias / Acetaminofen Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2017 Tipo de documento: Article