Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis.
Antimicrob Agents Chemother
; 61(3)2017 03.
Article
em En
| MEDLINE
| ID: mdl-28232309
ABSTRACT
We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Plantas_medicinales
Assunto principal:
Infecções Estafilocócicas
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Proteínas de Bactérias
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Vancomicina
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Daptomicina
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Farmacorresistência Bacteriana Múltipla
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Proteínas de Ligação às Penicilinas
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Endocardite Bacteriana
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Antibacterianos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos