[Performances of breast magnetic resonance imaging in the context of neoadjuvant chemotherapy for breast cancer to predict pathological complete response]. / Performances de l'imagerie par résonance magnétique au cours des chimiothérapies néoadjuvantes du cancer du sein pour prédire la réponse pathologique complète.
J Gynecol Obstet Hum Reprod
; 46(2): 147-154, 2017 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-28403971
ABSTRACT
PURPOSE:
The objective of this work was to estimate the reliability of MRI after neoadjuvant chemotherapy (NAC) for breast cancer to detect a residual tumour by comparing the tumoral size measured by MRI with the histological size. We also estimated the concordance of diagnosis of complete pathological response between histological examination and MRI. MATERIALS ANDMETHODS:
We included all the patients who received a neoadjuvant chemotherapy for breast cancer in the university hospital of Tours from January, 2008 to December 31st, 2012 and in the comprehensive cancer centre of Rennes from January, 2008 till May 31st 201. We considered that the pathological response was complete (pCR) when there was no residual invasive tumour in the mammary surgical specimen.RESULTS:
Two hundred and fifty-one women who received NAC for a non-metastatic breast cancer were included in the study 103 in Tours and 148 in Rennes. Two women (0.8%) refused breast surgery whatever the type. One hundred and twenty-three (49%) women had a breast conservative surgery. One hundred and fifteen (45.8%) had a mastectomy and 11 (4.4%) had breast conservative surgery followed by mastectomy for positive margins. A complete pathological response was present in 54 cases (21.5%). We did not found any significant difference between characteristics of patients with pCR or not.CONCLUSION:
Breast MRI remains the most performing examination to evaluate the initial tumoral size and the residual tumour after NAC, but does not add any value at mid or at the end of treatment for the patients to whom a mastectomy is decided at presentation. The correlation between the breast MRI and the histology size is not perfect, but at the moment, MRI stills of the most performing examination to predict the pCR.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mama
/
Neoplasias da Mama
/
Imageamento por Ressonância Magnética
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Carcinoma Ductal de Mama
Tipo de estudo:
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
Fr
Revista:
J Gynecol Obstet Hum Reprod
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
França