Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells.

Adedoyin, Oreoluwa; Boddu, Ravindra; Traylor, Amie; Lever, Jeremie M; Bolisetty, Subhashini; George, James F; Agarwal, Anupam

Adedoyin, Oreoluwa; Boddu, Ravindra; Traylor, Amie; Lever, Jeremie M; Bolisetty, Subhashini; George, James F; Agarwal, Anupam.

Afiliação

Adedoyin O; Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
Boddu R; Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
Traylor A; Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
Lever JM; Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
Bolisetty S; Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
George JF; Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
Agarwal A; Department of Surgery, University of Alabama at Birmingham , Birmingham, Alabama.

Am J Physiol Renal Physiol ; 314(5): F702-F714, 2018 05 01.

Article em En | MEDLINE | ID: mdl-28515173

Assuntos

Injúria Renal Aguda/enzimologia; Heme Oxigenase-1/metabolismo; Túbulos Renais Proximais/enzimologia; Proteínas de Membrana/metabolismo; Acetilcisteína/farmacologia; Injúria Renal Aguda/genética; Injúria Renal Aguda/patologia; Injúria Renal Aguda/prevenção & controle; Animais; Antioxidantes/farmacologia; Carbolinas/toxicidade; Morte Celular; Linhagem Celular; Cicloexilaminas/farmacologia; Desferroxamina/farmacologia; Relação Dose-Resposta a Droga; Compostos Férricos/toxicidade; Glutationa/metabolismo; Heme Oxigenase-1/deficiência; Heme Oxigenase-1/genética; Quelantes de Ferro/farmacologia; Túbulos Renais Proximais/efeitos dos fármacos; Túbulos Renais Proximais/patologia; Proteínas de Membrana/deficiência; Proteínas de Membrana/genética; Camundongos Knockout; Fenilenodiaminas/farmacologia; Piperazinas/toxicidade; Compostos de Amônio Quaternário/toxicidade; Transdução de Sinais; Fatores de Tempo

Palavras-chave

acute kidney injury; erastin; ferrostatin-1; iron; proximal tubule

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Heme Oxigenase-1 / Injúria Renal Aguda / Túbulos Renais Proximais / Proteínas de Membrana Tipo de estudo: Prognostic_studies Idioma: En Revista: Am J Physiol Renal Physiol Ano de publicação: 2018 Tipo de documento: Article

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