Effects of salt loading and potassium supplement on the circadian blood pressure profile in salt-sensitive Chinese patients.
Blood Press Monit
; 22(6): 307-313, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28628530
ABSTRACT
BACKGROUND AND OBJECTIVE:
Salt-sensitive (SS) patients more frequently showed a nondipper blood pressure pattern and were associated with more serious target organ damage than non-SS patients. We aimed to investigate whether potassium supplement can improve the blunted nocturnal blood pressure fall in SS patients exposed to a high-salt diet. PATIENTS ANDMETHODS:
Approximately 49 normotensive and mildly hypertensive Chinese patients received a study protocol of a 3 days of baseline examination, 7 days of a low-salt diet (3 g NaCl/day), 7 days of a high-salt diet (18 g NaCl/day), and 7 days of a high-salt diet with a potassium supplement (18 g NaCl and 4.5 g KCl/day). The 24 h ambulatory blood pressure was determined at the end of each period.RESULTS:
A total of 14 patients were classified as SS according to the at least 10% increase in their 24-h mean arterial pressure after high-salt loading. The night-to-day blood pressure ratio was significantly higher in SS patients than in non-SS patients during the high-salt loading period (systolic 0.96±0.01 vs. 0.89±0.01, P<0.01; diastolic 0.96±0.01 vs. 0.92±0.01, P<0.05). Compared with the high-salt loading period, the night-to-day blood pressure ratio was significantly reversed by potassium supplement in SS patients (systolic 0.91±0.01 vs. 0.96±0.01, P<0.05; diastolic 0.91±0.01 vs. 0.96±0.01, P<0.05).CONCLUSION:
Potassium supplement can improve the blunted nocturnal blood pressure fall in SS patients exposed to a high-salt diet, but the related mechanism needs to be studied further.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Potássio
/
Pressão Sanguínea
/
Ritmo Circadiano
/
Cloreto de Sódio na Dieta
/
Suplementos Nutricionais
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Blood Press Monit
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China