Oligomeric proanthocyanidin derived from grape seeds inhibited NF-&#954;B signaling in activated HSC: Involvement of JNK/ERK MAPK and PI3K/Akt pathways.

Jiang, Min; Wu, Yan-Ling; Li, Xia; Zhang, Yu; Xia, Kai-Li; Cui, Ben-Wen; Lian, Li-Hua; Nan, Ji-Xing

Oligomeric proanthocyanidin derived from grape seeds inhibited NF-κB signaling in activated HSC: Involvement of JNK/ERK MAPK and PI3K/Akt pathways.

Jiang, Min; Wu, Yan-Ling; Li, Xia; Zhang, Yu; Xia, Kai-Li; Cui, Ben-Wen; Lian, Li-Hua; Nan, Ji-Xing.

Afiliação

Jiang M; Clinical Research Center, Yanbian University Hospital, Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002 Jilin Province, China.
Wu YL; Clinical Research Center, Yanbian University Hospital, Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002 Jilin Province, China.
Li X; Clinical Research Center, Yanbian University Hospital, Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002 Jilin Province, China.
Zhang Y; Clinical Research Center, Yanbian University Hospital, Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002 Jilin Province, China.
Xia KL; Clinical Research Center, Yanbian University Hospital, Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002 Jilin Province, China.
Cui BW; Clinical Research Center, Yanbian University Hospital, Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002 Jilin Province, China.
Lian LH; Clinical Research Center, Yanbian University Hospital, Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002 Jilin Province, China. Electronic address: lhlian@ybu.edu.cn.
Nan JX; Clinical Research Center, Yanbian University Hospital, Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002 Jilin Province, China. Electronic address: jxnan@ybu.edu.cn.

Biomed Pharmacother ; 93: 674-680, 2017 Sep.

Article em En | MEDLINE | ID: mdl-28692939

Assuntos

Células Estreladas do Fígado/efeitos dos fármacos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; NF-kappa B/metabolismo; Fosfatidilinositol 3-Quinase/metabolismo; Proantocianidinas/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Sementes/química; Vitis/química; Animais; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Transdiferenciação Celular/efeitos dos fármacos; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Células Estreladas do Fígado/metabolismo; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; Fosforilação/efeitos dos fármacos; Extratos Vegetais/farmacologia; Ratos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Akt; Hepatic stellate cell; MAPK; Oligomeric proanthocyanidin; PI3K

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sementes / NF-kappa B / Sistema de Sinalização das MAP Quinases / Vitis / Proantocianidinas / Proteínas Proto-Oncogênicas c-akt / Células Estreladas do Fígado / Fosfatidilinositol 3-Quinase Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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