Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
Am J Clin Nutr
; 106(4): 1032-1040, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28768650
ABSTRACT
Background:
Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife.Objective:
We hypothesize that higher intake of these B vitamins in young adulthood is associated with better cognition later in life.Design:
This study comprised a community-based multicenter cohort of black and white men and women aged 18-30 y in 1985-1986 (year 0, i.e., baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3136). We examined participants' CARDIA diet history at years 0, 7, and 20 to assess nutrient intake, including dietary and supplemental B vitamins. We measured cognitive function at year 25 (mean ± SD age 50 ± 4 y) through the use of the Rey Auditory Verbal Learning Test (RAVLT) for verbal memory, the Digit Symbol Substitution Test (DSST) for psychomotor speed, and a modified Stroop interference test for executive function. Higher RAVLT and DSST scores and a lower Stroop score indicated better cognitive function. We used multivariable-adjusted linear regressions to estimate mean differences in cognitive scores and 95% CIs.Results:
Comparing the highest quintile with the lowest (quintile 5 compared with quintile 1), cumulative total intake of niacin was significantly associated with 3.92 more digits on the DSST (95% CI 2.28, 5.55; P-trend < 0.01) and 1.89 points lower interference score on the Stroop test (95% CI -3.10, -0.68; P-trend = 0.05). Total folate was associated with 2.56 more digits on the DSST (95% CI 0.82, 4.31; P-trend = 0.01). We also found that higher intakes of vitamin B-6 (quartile 5 compared with quartile 1 2.62; 95% CI 0.97, 4.28; P-trend = 0.02) and vitamin B-12 (quartile 5 compared with quartile 1 2.08; 95% CI 0.52, 3.65; P-trend = 0.02) resulted in better psychomotor speed measured by DSST scores.Conclusion:
Higher intake of B vitamins throughout young adulthood was associated with better cognitive function in midlife.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitamina B 12
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Complexo Vitamínico B
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Cognição
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Transtornos Cognitivos
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Vitamina B 6
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Ácido Fólico
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Niacina
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
2017
Tipo de documento:
Article