Baicalin suppresses IL-1ß-induced expression of inflammatory cytokines via blocking NF-&#954;B in human osteoarthritis chondrocytes and shows protective effect in mice osteoarthritis models.

Chen, Chunhui; Zhang, Chuanxu; Cai, Leyi; Xie, Huanguang; Hu, Wei; Wang, Te; Lu, Di; Chen, Hua

Baicalin suppresses IL-1ß-induced expression of inflammatory cytokines via blocking NF-κB in human osteoarthritis chondrocytes and shows protective effect in mice osteoarthritis models.

Chen, Chunhui; Zhang, Chuanxu; Cai, Leyi; Xie, Huanguang; Hu, Wei; Wang, Te; Lu, Di; Chen, Hua.

Afiliação

Chen C; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Zhang C; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Cai L; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Xie H; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Hu W; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Wang T; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Lu D; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Chen H; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: chenhuafey@126.com.

Int Immunopharmacol ; 52: 218-226, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28942223

Assuntos

Anti-Inflamatórios não Esteroides/uso terapêutico; Condrócitos/fisiologia; Flavonoides/uso terapêutico; NF-kappa B/metabolismo; Osteoartrite/tratamento farmacológico; Sinovite/tratamento farmacológico; Idoso; Agrecanas/metabolismo; Animais; Células Cultivadas; Condrócitos/efeitos dos fármacos; Citoproteção; Modelos Animais de Doenças; Feminino; Humanos; Terapia de Imunossupressão; Masculino; Camundongos; Pessoa de Meia-Idade; Óxido Nítrico/metabolismo; Scutellaria baicalensis/imunologia

Palavras-chave

Baicalin; Chondrocyte; Inflammation; NF-kB; Osteoarthritis

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas / Plantas_medicinales Assunto principal: Osteoartrite / Sinovite / Flavonoides / Anti-Inflamatórios não Esteroides / NF-kappa B / Condrócitos Tipo de estudo: Prognostic_studies Idioma: En Revista: Int Immunopharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google