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Mutagenicity and antimutagenicity of Salacia crassifolia (mart. Ex. Schult.) G. Don. evaluated by Ames test.
Carneiro, C C; Véras, J Holanda; Góes, B R Lima; Pérez, C N; Chen-Chen, L.
Afiliação
  • Carneiro CC; Departamento de Genética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil.
  • Véras JH; Departamento de Genética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil.
  • Góes BRL; Departamento de Genética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil.
  • Pérez CN; Instituto de Química, Universidade Federal de Goiás, Goiânia, GO, Brazil.
  • Chen-Chen L; Departamento de Genética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Braz J Biol ; 78(2): 345-350, 2018 May.
Article em En | MEDLINE | ID: mdl-28954013
ABSTRACT
Salacia crassifolia (Mart. Ex. Schult.) G. Don. is a bush which belongs to Celastraceae family and occurs specially in Brazilian Cerrado. Its leaves, stem, seeds and fruits are popularly used for several medicinal purposes, such as antitumoral, antirheumatic, anti-inflammatory and antimicrobial. In this study, the mutagenic and antimutagenic activities of S. crassifolia stem bark fractions (hexane, ethyl acetate and hydroalcoholic) were evaluated by the Ames mutagenicity assay in Salmonella typhimurium TA98 and TA100 strains. By the obtained results, all S. crassifolia fractions did not significantly increase the number of prototrophic revertants for histidine (His+) in both S. typhimurium strains tested (p > 0.05), suggesting absence of mutagenicity. Regarding antimutagenicity, the fractions ethyl acetate and hydroalcoholic significantly decreased the number of His+ revertants colonies induced by positive control for strain TA98 (p < 0.05), demonstrating protection against mutagenicity induced by 4-nitroquinolile1-oxide, whereas the hexane fraction did not show antimutagenic effect in this strain. In the TA100 strain, all fractions of S. crassifolia protected DNA against the harmful action of sodium azide, and the hexane fraction exhibited the greatest protection in this work. Thus, it's possible conclude that the fractions of S. crassifolia tested in this study could be used in chemoprevention.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antimutagênicos / Salacia / Mutagênicos Idioma: En Revista: Braz J Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antimutagênicos / Salacia / Mutagênicos Idioma: En Revista: Braz J Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil