RNA sequencing and proteomics approaches reveal novel deficits in the cortex of <i>Mecp2</i>-deficient mice, a model for Rett syndrome.

Pacheco, Natasha L; Heaven, Michael R; Holt, Leanne M; Crossman, David K; Boggio, Kristin J; Shaffer, Scott A; Flint, Daniel L; Olsen, Michelle L

RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome.

Pacheco, Natasha L; Heaven, Michael R; Holt, Leanne M; Crossman, David K; Boggio, Kristin J; Shaffer, Scott A; Flint, Daniel L; Olsen, Michelle L.

Afiliação

Pacheco NL; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd, Birmingham, AL 35294 USA.
Heaven MR; Vulcan Analytical, LLC, 1500 1st Ave. North, Birmingham, AL 35203 USA.
Holt LM; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd, Birmingham, AL 35294 USA.
Crossman DK; School of Neuroscience, Virginia Polytechnic and State University, Life Sciences Building Room 213, 970 Washington St. SW, Blacksburg, VA 24061 USA.
Boggio KJ; UAB Heflin Center for Genomic Science, Department of Genetics, University of Alabama at Birmingham, Kaul 424A, 1720 2nd Ave. South, Birmingham, AL 35294 USA.
Shaffer SA; Proteomics and Mass Spectrometry Facility, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 222 Maple Ave., Fuller Building, Shrewsbury, MA 01545 USA.
Flint DL; Proteomics and Mass Spectrometry Facility, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 222 Maple Ave., Fuller Building, Shrewsbury, MA 01545 USA.
Olsen ML; Luxumbra Strategic Research, LLC, 1331 South Eads St, Arlington, VA 22202 USA.

Mol Autism ; 8: 56, 2017.

Article em En | MEDLINE | ID: mdl-29090078

Assuntos

Córtex Cerebral/metabolismo; Proteína 2 de Ligação a Metil-CpG/genética; Proteoma/metabolismo; Proteômica; RNA/metabolismo; Síndrome de Rett/genética; Animais; Cromatografia Líquida de Alta Pressão; Modelos Animais de Doenças; Feminino; Genótipo; Masculino; Proteína 2 de Ligação a Metil-CpG/deficiência; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Neurônios/metabolismo; Fenótipo; Proteoma/análise; RNA/química; RNA/isolamento & purificação; Síndrome de Rett/patologia; Análise de Sequência de RNA; Espectrometria de Massas em Tandem; Transcriptoma

Palavras-chave

Multi-cellular deficits; Proteome; Rett syndrome; Transcriptome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA / Síndrome de Rett / Córtex Cerebral / Proteoma / Proteômica / Proteína 2 de Ligação a Metil-CpG Idioma: En Revista: Mol Autism Ano de publicação: 2017 Tipo de documento: Article

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