Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges.
Adv Healthc Mater
; 7(2)2018 01.
Article
em En
| MEDLINE
| ID: mdl-29205920
ABSTRACT
Traditional cell culture and animal models utilized for preclinical drug screening have led to high attrition rates of drug candidates in clinical trials due to their low predictive power for human response. Alternative models using human cells to build in vitro biomimetics of the human body with physiologically relevant organ-organ interactions hold great potential to act as "human surrogates" and provide more accurate prediction of drug effects in humans. This review is a comprehensive investigation into the development of tissue-engineered human cell-based microscale multiorgan models, or multiorgan microphysiological systems for drug testing. The evolution from traditional models to macro- and microscale multiorgan systems is discussed in regards to the rationale for recent global efforts in multiorgan microphysiological systems. Current advances in integrating cell culture and on-chip analytical technologies, as well as proof-of-concept applications for these multiorgan microsystems are discussed. Major challenges for the field, such as reproducibility and physiological relevance, are discussed with comparisons of the strengths and weaknesses of various systems to solve these challenges. Conclusions focus on the current development stage of multiorgan microphysiological systems and new trends in the field.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Engenharia Tecidual
/
Dispositivos Lab-On-A-Chip
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Adv Healthc Mater
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos