Echinacea purpurea Protects Against Restraint Stress-Induced Immunosuppression in BALB/c Mice.
J Med Food
; 21(3): 261-268, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-29215298
ABSTRACT
Echinacea purpurea has been widely used for the prevention and treatment of upper respiratory tract infections and the common cold. The restraint stress has been reported to suppress a broad spectrum of immune functions. The aim of this study was to investigate the protective effects of the pressed juice of E. purpurea (L.) Moench (EFLA®894; Echinacea) against restraint stress-induced immunosuppression in BALB/c mice. Echinacea significantly normalized the restraint stress-induced reduction in splenocyte proliferation and splenic natural killer (NK) cell activity (P < .05). Echinacea treatment significantly increased the percentages of CD4+ and CD8+ T lymphocytes in the blood (P < .05). In addition, Echinacea restored serum cytokine levels, including interleukin-6 (IL-6), interleukin-10 (IL-10), and interleukin-17 (IL-17), as well as the mRNA expressions of these cytokines in spleen (P < .05). Our findings suggest that Echinacea might have beneficial effects on restraint stress-induced immunosuppression by increasing splenocyte proliferation and NK cell activity, while modulating T lymphocyte subsets and cytokine levels in the blood.
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Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Assunto principal:
Estresse Fisiológico
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Estresse Psicológico
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Extratos Vegetais
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Anti-Inflamatórios não Esteroides
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Suplementos Nutricionais
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Echinacea
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Componentes Aéreos da Planta
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
J Med Food
Ano de publicação:
2018
Tipo de documento:
Article