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Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome.
Berry-Kravis, Elizabeth M; Lindemann, Lothar; Jønch, Aia E; Apostol, George; Bear, Mark F; Carpenter, Randall L; Crawley, Jacqueline N; Curie, Aurore; Des Portes, Vincent; Hossain, Farah; Gasparini, Fabrizio; Gomez-Mancilla, Baltazar; Hessl, David; Loth, Eva; Scharf, Sebastian H; Wang, Paul P; Von Raison, Florian; Hagerman, Randi; Spooren, Will; Jacquemont, Sébastien.
Afiliação
  • Berry-Kravis EM; Departments of Pediatrics, Neurological Sciences and Biochemistry, Rush University Medical Center, 1725 West Harrison Street, Suite 718, Chicago, Illinois 60612, USA.
  • Lindemann L; Roche Pharmaceuticals Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Jønch AE; Department of Clinical Genetics, Odense University Hospital, Sdr. Boulevard 29, Odense C, Denmark.
  • Apostol G; Human Genetics, Department of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19, 5000 Odense C, Denmark.
  • Bear MF; Formerly at Neuroscience Development, Novartis Pharma AG, Fabrikstrasse 2, 4056 Basel, Switzerland.
  • Carpenter RL; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, Massachusetts 02139, USA.
  • Crawley JN; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, Massachusetts 02139, USA.
  • Curie A; MIND Institute, University of California Davis School of Medicine, 2825 50th Street, Sacramento, California 95817, USA.
  • Des Portes V; Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, 4625 2nd Avenue, Sacramento, California 95817, USA.
  • Hossain F; National Reference Center for Rare Diseases with Intellectual Disability, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université de Lyon, Institut des Sciences Cognitives, CNRS UMR 5304, Boulevard Pinel 67, 69675 Bron Cedex, France.
  • Gasparini F; National Reference Center for Rare Diseases with Intellectual Disability, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université de Lyon, Institut des Sciences Cognitives, CNRS UMR 5304, Boulevard Pinel 67, 69675 Bron Cedex, France.
  • Gomez-Mancilla B; Neuroscience Development, Novartis Pharmaceutical Corporation, 1 Health Plaza, East Hanover, New Jersey 07936, USA.
  • Hessl D; Novartis Institutes for Biomedical Research, Neuroscience Research, Postfach, 4002 Basel, Switzerland.
  • Loth E; Novartis Institutes for Biomedical Research, Neuroscience Research, Postfach, 4002 Basel, Switzerland.
  • Scharf SH; Department of Neurology & Neurosurgery, McGill University, 845 Sherbrook Street West, Montreal, Quebec H3A 0G4, Canada.
  • Wang PP; MIND Institute, University of California Davis School of Medicine, 2825 50th Street, Sacramento, California 95817, USA.
  • Von Raison F; Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, 4625 2nd Avenue, Sacramento, California 95817, USA.
  • Hagerman R; Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.
  • Spooren W; Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Jacquemont S; Simons Foundation, 160 Fifth Avenue, 7th Floor, New York, New York 10010, USA.
Nat Rev Drug Discov ; 17(4): 280-299, 2018 04.
Article em En | MEDLINE | ID: mdl-29217836
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neurotransmissores / Transtornos do Neurodesenvolvimento / Síndrome do Cromossomo X Frágil Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Revista: Nat Rev Drug Discov Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neurotransmissores / Transtornos do Neurodesenvolvimento / Síndrome do Cromossomo X Frágil Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Revista: Nat Rev Drug Discov Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos