Biodegradable Hollow Mesoporous Organosilica Nanotheranostics for Mild Hyperthermia-Induced Bubble-Enhanced Oxygen-Sensitized Radiotherapy.
ACS Nano
; 12(2): 1580-1591, 2018 02 27.
Article
em En
| MEDLINE
| ID: mdl-29384652
ABSTRACT
Alleviation of tumor hypoxia has been the premise for improving the effectiveness of radiotherapy, which hinges upon the advanced delivery and rapid release of oxygen within the tumor region. Herein, we propose a "bubble-enhanced oxygen diffusion" strategy to achieve whole tumor oxygenation for significant radiation enhancement based on the "bystander effect". Toward this end, sub-50 nm CuS-modified and 64Cu-labeled hollow mesoporous organosilica nanoparticles were constructed for tumor-specific delivery of O2-saturated perfluoropentane (PFP). Through the aid of PFP gasification arising from NIR laser-triggered mild hyperthermia, simultaneous PET/PA/US multimodality imaging and rapid oxygen diffusion across the tumor can be achieved for remarkable hypoxic radiosensitization. Furthermore, the multifunctional oxygen-carrying nanotheranostics also allow for other oxygen-dependent treatments, thus greatly advancing the development of bubble-enhanced synergistic therapy platforms.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
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Compostos de Organossilício
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Nanopartículas
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Fluorocarbonos
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Nanomedicina Teranóstica
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Neoplasias
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
ACS Nano
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China