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Biodegradable Hollow Mesoporous Organosilica Nanotheranostics for Mild Hyperthermia-Induced Bubble-Enhanced Oxygen-Sensitized Radiotherapy.
Lu, Nan; Fan, Wenpei; Yi, Xuan; Wang, Sheng; Wang, Zhantong; Tian, Rui; Jacobson, Orit; Liu, Yijing; Yung, Bryant C; Zhang, Guofeng; Teng, Zhaogang; Yang, Kai; Zhang, Minming; Niu, Gang; Lu, Guangming; Chen, Xiaoyuan.
Afiliação
  • Lu N; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing, Jiangsu 210002, China.
  • Fan W; Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310009, China.
  • Yi X; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Wang S; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Wang Z; School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University , Suzhou, Jiangsu 215123, China.
  • Tian R; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Jacobson O; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Liu Y; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Yung BC; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Zhang G; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Teng Z; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Yang K; Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Zhang M; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing, Jiangsu 210002, China.
  • Niu G; School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University , Suzhou, Jiangsu 215123, China.
  • Lu G; Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310009, China.
  • Chen X; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
ACS Nano ; 12(2): 1580-1591, 2018 02 27.
Article em En | MEDLINE | ID: mdl-29384652
ABSTRACT
Alleviation of tumor hypoxia has been the premise for improving the effectiveness of radiotherapy, which hinges upon the advanced delivery and rapid release of oxygen within the tumor region. Herein, we propose a "bubble-enhanced oxygen diffusion" strategy to achieve whole tumor oxygenation for significant radiation enhancement based on the "bystander effect". Toward this end, sub-50 nm CuS-modified and 64Cu-labeled hollow mesoporous organosilica nanoparticles were constructed for tumor-specific delivery of O2-saturated perfluoropentane (PFP). Through the aid of PFP gasification arising from NIR laser-triggered mild hyperthermia, simultaneous PET/PA/US multimodality imaging and rapid oxygen diffusion across the tumor can be achieved for remarkable hypoxic radiosensitization. Furthermore, the multifunctional oxygen-carrying nanotheranostics also allow for other oxygen-dependent treatments, thus greatly advancing the development of bubble-enhanced synergistic therapy platforms.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Compostos de Organossilício / Nanopartículas / Fluorocarbonos / Nanomedicina Teranóstica / Neoplasias Tipo de estudo: Diagnostic_studies Idioma: En Revista: ACS Nano Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Compostos de Organossilício / Nanopartículas / Fluorocarbonos / Nanomedicina Teranóstica / Neoplasias Tipo de estudo: Diagnostic_studies Idioma: En Revista: ACS Nano Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China