Codonopsis lanceolata extract prevents hypertension in rats.
Phytomedicine
; 39: 119-124, 2018 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-29433673
ABSTRACT
BACKGROUND:
Codonopsis lanceolata, a plant with antioxidant, anti-cancer, anti-inflammatory and blood lipid improving effects, has been widely used as a therapeutic agent in traditional medicine.PURPOSE:
The present study investigated the ability of an ethanol extract of Codonopsis lanceolata (ECL) to prevent hypertension in hypertensive rats.METHODS:
Rats were orally administered daily doses of 0â¯mg/kg, 200â¯mg/kg and 400â¯mg/kg ECL for 3 weeks. As a positive control, rats were orally administered 10â¯mg/kg/day nifedipine. Hypertension was induced by immobilization stress for 2â¯h/day and by administration of 0.8â¯mg/kg/day nicotine for 3 weeks, followed by injection of 3â¯mg/kg nicotine on the day of sacrifice. Blood pressure and heart rate were measured using a volume pressure recording system. Vasoconstriction and vasodilation of aortic cross sections were measured with a physiological recorder. Neutrophil counts in bronchoalveolar lavage fluid were estimated with an automated cell counter.RESULTS:
Treatment with both dosages of ECL significantly reduced systolic blood pressure (SBP) in hypertensive rats. Both doses of ECL tended to increase ACh- and SNP-induced vascular relaxation in hypertensive rats. Treatment with 200â¯mg/kg ECL significantly reduced neutrophil in hypertensive rats.CONCLUSIONS:
These results suggest that ECL is effective in reducing SBP and inflammation in hypertensive conditions.Palavras-chave
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Extratos Vegetais
/
Codonopsis
/
Hipertensão
/
Anti-Hipertensivos
Idioma:
En
Revista:
Phytomedicine
Ano de publicação:
2018
Tipo de documento:
Article