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Shikonin exerts antitumor activity in Burkitt's lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin.
Ni, Fan; Huang, Xianbo; Chen, Zhenzhen; Qian, Wenbin; Tong, Xiangmin.
Afiliação
  • Ni F; The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, P.R. China.
  • Huang X; Clinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, P.R. China.
  • Chen Z; Malignant Lymphoma Diagnosis and Therapy Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.
  • Qian W; Malignant Lymphoma Diagnosis and Therapy Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.
  • Tong X; Malignant Lymphoma Diagnosis and Therapy Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China. qianwb@zju.edu.cn.
Sci Rep ; 8(1): 3317, 2018 02 20.
Article em En | MEDLINE | ID: mdl-29463831
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doxorrubicina / Proteínas Proto-Oncogênicas c-myc / Linfoma de Burkitt / Naftoquinonas / Sinergismo Farmacológico / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doxorrubicina / Proteínas Proto-Oncogênicas c-myc / Linfoma de Burkitt / Naftoquinonas / Sinergismo Farmacológico / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article