Two new sesquineolignans from the seeds of Crataegus pinnatifida and their ß-amyloid aggregation inhibitory activitiy.
Nat Prod Res
; 33(17): 2446-2452, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-29521116
Two new sesquineolignans, hawthornsesquinins K and L (1 and 2), were isolated from the seeds of Crataegus pinnatifida. Their structures were determined by spectroscopic analyses, including 1D, 2D NMR and HRESIMS data. All isolated compounds were tested for their ß-amyloid aggregation inhibitory activity and neuroprotective effects against H2O2-induced damage in SH-SY5Y cells. The results indicated that compound 1 showed prominent inhibition of Aß1-42 aggregation and significant neuroprotective effect on H2O2-induced cellular damage in SH-SY5Y cells.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Peptídeos beta-Amiloides
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Lignanas
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Fármacos Neuroprotetores
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Crataegus
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China