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Two new sesquineolignans from the seeds of Crataegus pinnatifida and their ß-amyloid aggregation inhibitory activitiy.
Guo, Rui; Zhou, Le; Zhao, Peng; Wang, Xiao-Bo; Huang, Xiao-Xiao; Song, Shao-Jiang.
Afiliação
  • Guo R; a School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang , China.
  • Zhou L; a School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang , China.
  • Zhao P; a School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang , China.
  • Wang XB; b Chinese People's Liberation Army 210 Hospital , Dalian , China.
  • Huang XX; a School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang , China.
  • Song SJ; b Chinese People's Liberation Army 210 Hospital , Dalian , China.
Nat Prod Res ; 33(17): 2446-2452, 2019 Sep.
Article em En | MEDLINE | ID: mdl-29521116
Two new sesquineolignans, hawthornsesquinins K and L (1 and 2), were isolated from the seeds of Crataegus pinnatifida. Their structures were determined by spectroscopic analyses, including 1D, 2D NMR and HRESIMS data. All isolated compounds were tested for their ß-amyloid aggregation inhibitory activity and neuroprotective effects against H2O2-induced damage in SH-SY5Y cells. The results indicated that compound 1 showed prominent inhibition of Aß1-42 aggregation and significant neuroprotective effect on H2O2-induced cellular damage in SH-SY5Y cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Lignanas / Fármacos Neuroprotetores / Crataegus Idioma: En Revista: Nat Prod Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Lignanas / Fármacos Neuroprotetores / Crataegus Idioma: En Revista: Nat Prod Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China