Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization.

Jiang, Mei; Liu, Xinghui; Zhang, Denghai; Wang, Ying; Hu, Xiaoxia; Xu, Fengxia; Jin, Mingming; Cao, Fanfan; Xu, Limin

Jiang, Mei; Liu, Xinghui; Zhang, Denghai; Wang, Ying; Hu, Xiaoxia; Xu, Fengxia; Jin, Mingming; Cao, Fanfan; Xu, Limin.

Afiliação

Jiang M; Department of neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, 200135, People's Republic of China.
Liu X; Department of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, 207 Ju Ye Road, Pudong New Area, Shanghai, 200135, People's Republic of China.
Zhang D; Sino-French Cooperative Central Lab, Shanghai Gongli Hospital, The Second Military Medical University, 207 Ju Ye Road, Pudong New District, Shanghai, 200135, People's Republic of China.
Wang Y; Sino-French Cooperative Central Lab, Shanghai Gongli Hospital, The Second Military Medical University, 207 Ju Ye Road, Pudong New District, Shanghai, 200135, People's Republic of China.
Hu X; Department of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, 207 Ju Ye Road, Pudong New Area, Shanghai, 200135, People's Republic of China.
Xu F; Department of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, 207 Ju Ye Road, Pudong New Area, Shanghai, 200135, People's Republic of China.
Jin M; Department of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, 207 Ju Ye Road, Pudong New Area, Shanghai, 200135, People's Republic of China. asdjinmingming@126.com.
Cao F; Sino-French Cooperative Central Lab, Shanghai Gongli Hospital, The Second Military Medical University, 207 Ju Ye Road, Pudong New District, Shanghai, 200135, People's Republic of China. yffs.c@163.com.
Xu L; Department of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, 207 Ju Ye Road, Pudong New Area, Shanghai, 200135, People's Republic of China. 13564378807@163.com.

J Neuroinflammation ; 15(1): 78, 2018 Mar 14.

Article em En | MEDLINE | ID: mdl-29540209

Assuntos

Lesões Encefálicas/tratamento farmacológico; Polaridade Celular/efeitos dos fármacos; Proteína 1 Semelhante a Receptor de Interleucina-1/metabolismo; Interleucina-3/metabolismo; Triterpenos/uso terapêutico; Idoso; Animais; Apoptose/efeitos dos fármacos; Infarto Encefálico/tratamento farmacológico; Infarto Encefálico/etiologia; Lesões Encefálicas/etiologia; Isquemia Encefálica/complicações; Técnicas de Cocultura; Modelos Animais de Doenças; Feminino; Humanos; Proteína 1 Semelhante a Receptor de Interleucina-1/genética; Macrófagos/efeitos dos fármacos; Masculino; Microglia/efeitos dos fármacos; Pessoa de Meia-Idade; Fármacos Neuroprotetores/farmacologia; Fármacos Neuroprotetores/uso terapêutico; Triterpenos Pentacíclicos; Ratos; Ratos Sprague-Dawley; Recuperação de Função Fisiológica/efeitos dos fármacos; Filtro Sensorial/efeitos dos fármacos; Acidente Vascular Cerebral/complicações; Acidente Vascular Cerebral/etiologia

Palavras-chave

Acute ischemic stroke; Celastrol; IL-33; M2 microglia/macrophage polarization; ST2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Lesões Encefálicas / Interleucina-3 / Polaridade Celular / Proteína 1 Semelhante a Receptor de Interleucina-1 Tipo de estudo: Etiology_studies / Prognostic_studies Idioma: En Revista: J Neuroinflammation Ano de publicação: 2018 Tipo de documento: Article

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