Therapeutic effects of Artemisia scoparia Waldst. et Kitaib in a murine model of atopic dermatitis.
Clin Exp Dermatol
; 43(7): 798-805, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-29740850
ABSTRACT
BACKGROUND:
Artemisia scoparia Waldst. et Kitaib (AS) (Oriental wormwood, known as Bissuk in Korea) is a plant used in cosmetic and pharmaceutical treatments. However, the effect of AS on atopic dermatitis (AD) has not been described.AIM:
To examine the inhibitory effect of AS on AD using a murine model.METHODS:
We applied either AS, the butanol-extracted fraction of AS (Bu-OH) or 3,5-dicaffeoyl-epi-quinic acid (DEQA, a major component of Bu-OH) topically for 3 weeks to 2,4-dinitrofluorobenzene (DNFB)-induced skin lesions in BALB/c mice.RESULTS:
AS, Bu-OH and DEQA suppressed the clinical symptoms of DNFB-induced skin lesions and he associated scratching behaviour. Numbers of inflammatory cells infiltrating skin lesions were significantly reduced by AS or Bu-OH application but not by DEQA. In addition, AS significantly suppressed serum levels of histamine and IgE, while Bu-OH significantly suppressed serum levels of histamine, IgE, thymic stromal lymphopoietin (TSLP), interleukin (IL)-4 and IL-6, and DEQA significantly suppressed serum levels of histamine, IgE, TSLP and IL-4 in DNFB-induced AD mice. In skin lesions, AS and Bu-OH significantly reduced inflammatory cytokines, whereas DEQA did not. AS, Bu-OH and DEQA all significantly suppressed caspase-1 activities.CONCLUSIONS:
These results demonstrate the anti-AD effects of AS, Bu-OH and DEQA, and suggest that all three have therapeutic potential.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
Assunto principal:
Extratos Vegetais
/
Ácido Clorogênico
/
Artemisia
/
Caspase 1
/
Dermatite Atópica
/
Fitoterapia
Idioma:
En
Revista:
Clin Exp Dermatol
Ano de publicação:
2018
Tipo de documento:
Article