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Syzygium aqueum: A Polyphenol- Rich Leaf Extract Exhibits Antioxidant, Hepatoprotective, Pain-Killing and Anti-inflammatory Activities in Animal Models.
Sobeh, Mansour; Mahmoud, Mona F; Petruk, Ganna; Rezq, Samar; Ashour, Mohamed L; Youssef, Fadia S; El-Shazly, Assem M; Monti, Daria M; Abdel-Naim, Ashraf B; Wink, Michael.
Afiliação
  • Sobeh M; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.
  • Mahmoud MF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
  • Petruk G; Department of Chemical Sciences, University of Naples Federico II, Naples, Italy.
  • Rezq S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
  • Ashour ML; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University Abbassia, Cairo, Egypt.
  • Youssef FS; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University Abbassia, Cairo, Egypt.
  • El-Shazly AM; Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
  • Monti DM; Department of Chemical Sciences, University of Naples Federico II, Naples, Italy.
  • Abdel-Naim AB; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Wink M; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.
Front Pharmacol ; 9: 566, 2018.
Article em En | MEDLINE | ID: mdl-29922158
ABSTRACT
Syzygium aqueum is widely used in folk medicine. A polyphenol-rich extract from its leaves demonstrated a plethora of substantial pharmacological properties. The extract showed solid antioxidant properties in vitro and protected human keratinocytes (HaCaT cells) against UVA damage. The extract also reduced the elevated levels of ALT, AST, total bilirubin (TB), total cholesterol (TC) and triglycerides (TG) in rats with acute CCl4 intoxication. In addition to reducing the high MDA level, the extract noticeably restored GSH and SOD to the normal control levels in liver tissue homogenates and counteracted the deleterious histopathologic changes in liver after CCl4 injection. Additionally, the extract exhibited promising anti-inflammatory activities in vitro where it inhibited LOX, COX-1, and COX-2 with a higher COX-2 selectivity than that of indomethacin and diclofenac and reduced the extent of lysis of erythrocytes upon incubation with hypotonic buffer solution. S. aqueum extract also markedly reduced leukocyte numbers with similar activities to diclofenac in rats challenged with carrageenan. Additionally, administration of the extract abolished writhes induced by acetic acid in mice and prolonged the response latency in hot plate test. Meanwhile, the identified polyphenolics from the extract showed a certain affinity for the active pockets of 5-lipoxygenase (5-LOX), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) explaining the observed anti-inflammatory activities. Finally, 87 secondary metabolites (mostly phenolics) were tentatively identified in the extract based on LC-MS/MS analyses. Syzygium aqueum displays good protection against oxidative stress, free radicals, and could be a good candidate for treating oxidative stress related diseases.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha