Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study.
Transpl Int
; 32(1): 49-58, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30099788
ABSTRACT
Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency [25-OH vitamin D (25-OHD) <50 nmol/l] and no deficiency (25-OHD ≥50 nmol/l) in incident infections after liver transplantation. In 135 liver transplant recipients, blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the Swiss Transplant Cohort Study database. Poisson regression was applied to address associations between vitamin D status and incident infections. Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses, vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant incidence rate ratio (IRR 1.52, 95% CI 1.08-2.15, P = 0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P = 0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders. Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
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Vitamina D
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Transplante de Fígado
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Falência Hepática
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
País/Região como assunto:
Europa
Idioma:
En
Revista:
Transpl Int
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Suíça