Your browser doesn't support javascript.
loading
Association of Antioxidative Enzymes Polymorphisms with Efficacy of Platin and Fluorouracil-Based Adjuvant Therapy in Gastric Cancer.
Zhang, Honghong; Zhao, Weiyong; Gu, Dongying; Du, Mulong; Gong, Weida; Tan, Yongfei; Wang, Meilin; Wen, Juan; Zhai, Yongning; Xu, Zhi.
Afiliação
  • Zhang H; Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Zhao W; Department of Oncology, Taizhou People's Hospital, Taizhou, China.
  • Gu D; Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Du M; Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Gong W; Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Tan Y; Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
  • Wang M; Department of Surgery, Yixing Cancer Hospital, Yixing, China.
  • Wen J; Department of Surgery, Yixing People's Hospital, Yixing, China.
  • Zhai Y; Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
  • Xu Z; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Cell Physiol Biochem ; 48(6): 2247-2257, 2018.
Article em En | MEDLINE | ID: mdl-30114685
BACKGROUND/AIMS: Imbalance of oxidative/antioxidative enzymes in cells is associated with carcinogenesis and cancer cell chemoresistance. The aim of this study was to examine the clinical significance of potentially functional single nucleotides polymorphisms (SNPs) in antioxidative enzymes, GPxs and CAT, in stages II and III gastric cancer patients. METHODS: A total of 591 gastric cancer patients who had radical gastrectomy were recruited. 207 patients received platinum and fluorouracil-based (PF-based) adjuvant chemotherapy and 384 patients were untreated. GPx1 rs1050450, GPx2 rs4902346, GPx3 rs736775, rs3828599 and CAT rs769218 were genotyped in the DNA samples extracted from paraffin-embedded tumor tissue. RESULTS: CAT rs769218 was significantly correlated with the overall survival (OS) in the dominant model (P = 0.014). Multivariate analysis revealed that CAT rs769218 GA/AA (HR, 0.715; 95%CI, 0.562-0.910, P = 0.006) was an independent prognostic marker indicating improved survival. After adjustments, GPx3 rs736775 TC/CC was significantly associated with improved OS (HR, 0.621; 95%CI, 0.399-0.965; P=0.034) in patients treated with PF-based adjuvant chemotherapy, and CAT rs769218 GA/AA was significantly associated with improved OS (HR, 0.646; 95% CI, 0.482-0.864; P = 0.003) in the untreated patients. PF-based chemotherapy significantly decreased risk of death for patients carrying GPx3 rs736775 TC/CC and age ≤ 60 years or with diffused type adenocarcinoma compared to surgery alone. CONCLUSION: our findings suggested CAT rs769218 and GPx3 rs736775 may be considered as prognostic markers in gastric cancer. Patient stratification by GPx3 rs736775 and conventional pathological parameters may provide additional predictive information in treatment decision-making.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Catalase / Compostos de Platina / Fluoruracila / Glutationa Peroxidase Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cell Physiol Biochem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Catalase / Compostos de Platina / Fluoruracila / Glutationa Peroxidase Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cell Physiol Biochem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China