Bottom-up synthesis of MoS2 nanospheres for photothermal treatment of tumors.
Photochem Photobiol Sci
; 17(10): 1337-1345, 2018 Oct 10.
Article
em En
| MEDLINE
| ID: mdl-30141822
ABSTRACT
Photothermal therapy (PTT) is providing new opportunities for killing cancer cells. In this work, we introduce a new nanomedicine based on spherical MoS2 nanoparticles for PTT treatment of tumors, prepared using "green" bottom-up technology. To increase water solubility and avoid rapid clearance by the reticuloendothelial system, polyethylene glycol (PEG) was used to coat them. These MoS2-PEG nanospheres with an appropriate size (â¼100 nm) exhibit high photothermal conversion efficiency (26.7%). In vitro cellular studies revealed that the MoS2-PEG nanospheres showed negligible cytotoxicity. Additionally, through combining the MoS2-PEG nanosphere samples with NIR irradiation at 808 nm, excellent in vitro tumor cell killing efficacy was achieved. In the 4T1 tumor model, the MoS2-PEG nanospheres exhibited good antitumor efficiency in vivo, displaying complete tumor inhibition over 16 days after treatment. Therefore, MoS2-PEG nanospheres played an important role in tumor destruction, and this concept for developing spherical MoS2-based nanomedicines can serve as a platform technology for the next generation of in vivo PTT agents.
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Base de dados:
MEDLINE
Assunto principal:
Fototerapia
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Neoplasias da Mama
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Nanotecnologia
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Dissulfetos
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Nanosferas
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Molibdênio
Idioma:
En
Revista:
Photochem Photobiol Sci
Ano de publicação:
2018
Tipo de documento:
Article