Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy.

Chan-Hyams, Jasmine V E; Copp, Janine N; Smaill, Jeff B; Patterson, Adam V; Ackerley, David F

Chan-Hyams, Jasmine V E; Copp, Janine N; Smaill, Jeff B; Patterson, Adam V; Ackerley, David F.

Afiliação

Chan-Hyams JVE; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand; Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand.
Copp JN; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand; Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Smaill JB; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Patterson AV; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Ackerley DF; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand; Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland

Biochem Pharmacol ; 158: 192-200, 2018 12.

Article em En | MEDLINE | ID: mdl-30352235

Assuntos

Escherichia coli/metabolismo; Terapia Genética/métodos; Vetores Genéticos/metabolismo; Nitrorredutases/metabolismo; Pró-Fármacos/metabolismo; Aziridinas/metabolismo; Aziridinas/farmacologia; Relação Dose-Resposta a Droga; Avaliação Pré-Clínica de Medicamentos/métodos; Escherichia coli/efeitos dos fármacos; Vetores Genéticos/farmacologia; Humanos; Pró-Fármacos/farmacologia

Palavras-chave

BDEPT; Bystander effect; Cancer gene therapy; GDEPT; Nitroreductase

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nitrorredutases / Pró-Fármacos / Terapia Genética / Escherichia coli / Vetores Genéticos Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Nova Zelândia

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google