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The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids.
Huang, Peng; Zhang, Yan; Xiao, Kangpeng; Jiang, Fan; Wang, Hengchao; Tang, Dazhi; Liu, Dan; Liu, Bo; Liu, Yisong; He, Xi; Liu, Hua; Liu, Xiubin; Qing, Zhixing; Liu, Conghui; Huang, Jialu; Ren, Yuwei; Yun, Long; Yin, Lijuan; Lin, Qian; Zeng, Cheng; Su, Xiaogang; Yuan, Jingyang; Lin, Li; Hu, Nanxi; Cao, Hualiang; Huang, Sanwen; Guo, Yuming; Fan, Wei; Zeng, Jianguo.
Afiliação
  • Huang P; Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Zhang Y; College of Horticulture and Landscape, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Xiao K; Agricultural Genomic Institute, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, Guangdong, China.
  • Jiang F; Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Wang H; College of Horticulture and Landscape, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Tang D; Agricultural Genomic Institute, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, Guangdong, China.
  • Liu D; Agricultural Genomic Institute, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, Guangdong, China.
  • Liu B; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
  • Liu Y; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
  • He X; Agricultural Genomic Institute, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, Guangdong, China.
  • Liu H; Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Liu X; College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Qing Z; College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Liu C; National and Local Union Engineering Research Center of Veterinary Herbal Medicine Resource and Initiative, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Huang J; Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Ren Y; Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Yun L; Agricultural Genomic Institute, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, Guangdong, China.
  • Yin L; Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Lin Q; College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Zeng C; Agricultural Genomic Institute, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, Guangdong, China.
  • Su X; College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Yuan J; Agricultural Genomic Institute, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, Guangdong, China.
  • Lin L; College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Hu N; Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Cao H; College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Huang S; College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Guo Y; College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Fan W; Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
  • Zeng J; College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, Hunan, China.
Microbiome ; 6(1): 211, 2018 11 27.
Article em En | MEDLINE | ID: mdl-30482240
ABSTRACT

BACKGROUND:

Sub-therapeutic antibiotics are widely used as growth promoters in the poultry industry; however, the resulting antibiotic resistance threatens public health. A plant-derived growth promoter, Macleaya cordata extract (MCE), with effective ingredients of benzylisoquinoline alkaloids, is a potential alternative to antibiotic growth promoters. Altered intestinal microbiota play important roles in growth promotion, but the underlying mechanism remains unknown.

RESULTS:

We generated 1.64 terabases of metagenomic data from 495 chicken intestinal digesta samples and constructed a comprehensive chicken gut microbial gene catalog (9.04 million genes), which is also the first gene catalog of an animal's gut microbiome that covers all intestinal compartments. Then, we identified the distinctive characteristics and temporal changes in the foregut and hindgut microbiota. Next, we assessed the impact of MCE on chickens and gut microbiota. Chickens fed with MCE had improved growth performance, and major microbial changes were confined to the foregut, with the predominant role of Lactobacillus being enhanced, and the amino acids, vitamins, and secondary bile acids biosynthesis pathways being upregulated, but lacked the accumulation of antibiotic-resistance genes. In comparison, treatment with chlortetracycline similarly enriched some biosynthesis pathways of nutrients in the foregut microbiota, but elicited an increase in antibiotic-producing bacteria and antibiotic-resistance genes.

CONCLUSION:

The reference gene catalog of the chicken gut microbiome is an important supplement to animal gut metagenomes. Metagenomic analysis provides insights into the growth-promoting mechanism of MCE, and underscored the importance of utilizing safe and effective growth promoters.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Galinhas / Substâncias de Crescimento / Benzilisoquinolinas / Lactobacillus Tipo de estudo: Prognostic_studies Idioma: En Revista: Microbiome Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Galinhas / Substâncias de Crescimento / Benzilisoquinolinas / Lactobacillus Tipo de estudo: Prognostic_studies Idioma: En Revista: Microbiome Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China