Esculentoside B inhibits inflammatory response through JNK and downstream NF-&#954;B signaling pathway in LPS-triggered murine macrophage RAW 264.7 cells.

Abekura, Fukushi; Park, Junyoung; Kwak, Choong-Hwan; Ha, Sun-Hyung; Cho, Seung-Hak; Chang, Young-Chae; Ha, Ki-Tae; Chang, Hyeun-Wook; Lee, Young-Choon; Chung, Tae-Wook; Kim, Cheorl-Ho

Esculentoside B inhibits inflammatory response through JNK and downstream NF-κB signaling pathway in LPS-triggered murine macrophage RAW 264.7 cells.

Abekura, Fukushi; Park, Junyoung; Kwak, Choong-Hwan; Ha, Sun-Hyung; Cho, Seung-Hak; Chang, Young-Chae; Ha, Ki-Tae; Chang, Hyeun-Wook; Lee, Young-Choon; Chung, Tae-Wook; Kim, Cheorl-Ho.

Afiliação

Abekura F; Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University, Seoburo 2066, Jangan-Gu, Suwon, Gyunggi-Do 16419, Republic of Korea.
Park J; Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University, Seoburo 2066, Jangan-Gu, Suwon, Gyunggi-Do 16419, Republic of Korea.
Kwak CH; Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University, Seoburo 2066, Jangan-Gu, Suwon, Gyunggi-Do 16419, Republic of Korea; Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan City, Gyeongsangnam-Do, Republic of K
Ha SH; Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University, Seoburo 2066, Jangan-Gu, Suwon, Gyunggi-Do 16419, Republic of Korea.
Cho SH; Division of Enteric Diseases, Center for Infectious Diseases Research, Korea National Institute of Health, Heungdeok-gu, Cheongju 363-951, Republic of Korea.
Chang YC; Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea. Electronic address: ycchang@cu.ac.kr.
Ha KT; Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan City, Gyeongsangnam-Do, Republic of Korea. Electronic address: haggis@pnu.ac.kr.
Chang HW; College of Pharmacy, Yeungnam University, Gyeongsan 701-947, Republic of Korea.
Lee YC; Faculty of Medicinal Biotechnology, Dong-A University, Saha-Gu, Busan, Republic of Korea. Electronic address: yclee@dau.ac.kr.
Chung TW; Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan City, Gyeongsangnam-Do, Republic of Korea.
Kim CH; Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University, Seoburo 2066, Jangan-Gu, Suwon, Gyunggi-Do 16419, Republic of Korea. Electronic address: chkimbio@skku.edu.

Int Immunopharmacol ; 68: 156-163, 2019 Mar.

Article em En | MEDLINE | ID: mdl-30639961

Assuntos

Anti-Inflamatórios não Esteroides/química; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; NF-kappa B/metabolismo; Saponinas/química; Terpenos/química; Animais; Anti-Inflamatórios não Esteroides/farmacologia; Sobrevivência Celular/efeitos dos fármacos; Citocinas/genética; Citocinas/metabolismo; Lipopolissacarídeos; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Camundongos; Óxido Nítrico/metabolismo; Células RAW 264.7; Saponinas/farmacologia; Transdução de Sinais/efeitos dos fármacos; Terpenos/farmacologia

Palavras-chave

Esculentoside B; Inflammation; JNK pathway; LPS; RAW264.7 cells

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Saponinas / Terpenos / Anti-Inflamatórios não Esteroides / NF-kappa B / Proteínas Quinases JNK Ativadas por Mitógeno Idioma: En Revista: Int Immunopharmacol Ano de publicação: 2019 Tipo de documento: Article

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