Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2&#945;-ATF4-CHOP Pathway.

Chen, Ming-Tai; Huang, Ruo-Lan; Ou, Li-Jun; Chen, Ying-Nan; Men, Ling; Chang, Xiao; Wang, Ling; Yang, Yu-Zhu; Zhang, Zhong

Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2α-ATF4-CHOP Pathway.

Chen, Ming-Tai; Huang, Ruo-Lan; Ou, Li-Jun; Chen, Ying-Nan; Men, Ling; Chang, Xiao; Wang, Ling; Yang, Yu-Zhu; Zhang, Zhong.

Afiliação

Chen MT; Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518000, Guangdong Province, China.
Huang RL; Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518000, Guangdong Province, China.
Ou LJ; Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518000, Guangdong Province, China.
Chen YN; Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518000, Guangdong Province, China.
Men L; Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518000, Guangdong Province, China.
Chang X; Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518000, Guangdong Province, China.
Wang L; Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518000, Guangdong Province, China.
Yang YZ; Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518000, Guangdong Province, China.
Zhang Z; Cardiovascular Department, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518000, Guangdong Province, China. szszyyzz@163.com.

Chin J Integr Med ; 25(8): 604-612, 2019 Aug.

Article em En | MEDLINE | ID: mdl-30707413

Assuntos

Apoptose/efeitos dos fármacos; Regulação para Baixo; Medicamentos de Ervas Chinesas/farmacologia; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Flavonas/farmacologia; Músculo Liso Vascular/patologia; Miócitos de Músculo Liso/patologia; Transdução de Sinais; Fator 4 Ativador da Transcrição/metabolismo; Aorta/patologia; Proliferação de Células/efeitos dos fármacos; Fator de Iniciação 2 em Eucariotos/metabolismo; Humanos; Miócitos de Músculo Liso/efeitos dos fármacos; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Transdução de Sinais/efeitos dos fármacos; Fator de Transcrição CHOP/metabolismo; eIF-2 Quinase/metabolismo

Palavras-chave

Pollen Typhae total flavone; apoptosis; endoplasmic reticulum stress; protein kinase RNA-like endoplasmic reticulum kinase-eukaryotic translation initiation factor 2α-activating transcription factor 4-CCAAT/enhancer binding protein homologous protein pathway; vulnerable atherosclerotic plaque

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Medicamentos de Ervas Chinesas / Transdução de Sinais / Regulação para Baixo / Apoptose / Miócitos de Músculo Liso / Flavonas / Estresse do Retículo Endoplasmático / Músculo Liso Vascular Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Revista: Chin J Integr Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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