Differential effect of grape seed extract and its active constituent procyanidin B2 3,3â³-di-O-gallate against prostate cancer stem cells.

Tyagi, Alpna; Kumar, Sushil; Raina, Komal; Wempe, Michael F; Maroni, Paul D; Agarwal, Rajesh; Agarwal, Chapla

Differential effect of grape seed extract and its active constituent procyanidin B2 3,3â³-di-O-gallate against prostate cancer stem cells.

Tyagi, Alpna; Kumar, Sushil; Raina, Komal; Wempe, Michael F; Maroni, Paul D; Agarwal, Rajesh; Agarwal, Chapla.

Afiliação

Tyagi A; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Kumar S; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Raina K; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Wempe MF; Department of Pharmaceutical Sciences, South Dakota State University, Brookings, South Dakota.
Maroni PD; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Agarwal R; University of Colorado Cancer Center, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Agarwal C; Department of Surgery-Urology Oncology, University of Colorado Hospital, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.

Mol Carcinog ; 58(7): 1105-1117, 2019 07.

Article em En | MEDLINE | ID: mdl-30828884

Assuntos

Antocianinas/farmacologia; Antineoplásicos Fitogênicos/farmacologia; Biflavonoides/farmacologia; Catequina/farmacologia; Extrato de Sementes de Uva/farmacologia; Células-Tronco Neoplásicas/efeitos dos fármacos; Proantocianidinas/farmacologia; Neoplasias da Próstata/tratamento farmacológico; Apoptose/efeitos dos fármacos; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Humanos; Proteína Jagged-1/metabolismo; Masculino; Células-Tronco Neoplásicas/patologia; Células PC-3; Próstata/patologia; Neoplasias da Próstata/patologia; Receptor Notch1/metabolismo; Esferoides Celulares/efeitos dos fármacos; Células Tumorais Cultivadas

Palavras-chave

chemoprevention; grape seed extract; procyanidin B2 3,3â³-di-O-gallate; procyanidins; prostate cancer; prostate cancer stem cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Células-Tronco Neoplásicas / Catequina / Biflavonoides / Proantocianidinas / Extrato de Sementes de Uva / Antocianinas / Antineoplásicos Fitogênicos Idioma: En Revista: Mol Carcinog Ano de publicação: 2019 Tipo de documento: Article

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