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The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature.
Zwolak, Iwona.
Afiliação
  • Zwolak I; Laboratory of Oxidative Stress, Centre for Interdisciplinary Research, The John Paul II Catholic University of Lublin, Konstantynów 1 J, 20-708, Lublin, Poland. iglina@kul.lublin.pl.
Biol Trace Elem Res ; 193(1): 44-63, 2020 Jan.
Article em En | MEDLINE | ID: mdl-30877523
Arsenic (As) and cadmium (Cd) are elements arousing major public health concerns associated with environmental pollution, high toxicity potential, and carcinogenic nature. However, selenium (Se) at low doses and incorporated into enzymes and proteins has antioxidant properties and protects animals and humans from the risk of various diseases. It also has an exceptionally narrow range between necessary and toxic concentrations, which is a well-known hindrance in its use as a dietary supplement. The present article aims to update and expand the role of Se in As and Cd toxicity discussed in our earlier paper. In general, recent reports show that Se, regardless of its form (as selenite, selenomethionine, nanoSe, or Se from lentils), can reduce As- or Cd-mediated toxicity in the liver, kidney, spleen, brain, or heart in animal models and in cell culture studies. As was suggested in our earlier review, Se antagonizes the toxicity of As and Cd mainly through sequestration of these elements into biologically inert complexes and/or through the action of Se-dependent antioxidant enzymes. An increase in the As methylation efficiency is proposed as a possible mechanism by which Se can reduce As toxicity. However, new studies indicate that Se may also diminish As or Cd toxicity by activation of the Nrf2 pathway. In addition, this paper discusses possible signs of Se toxic effects, which may be a challenge for its future use in the therapy of As and Cd poisoning and provide future directions to address this issue.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arsênio / Selênio / Cádmio Tipo de estudo: Prognostic_studies Idioma: En Revista: Biol Trace Elem Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Polônia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arsênio / Selênio / Cádmio Tipo de estudo: Prognostic_studies Idioma: En Revista: Biol Trace Elem Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Polônia