[Mechanism of Shenbing decoction â
¢ in the treatment of proteinuria in chronic kidney disease: a network pharmacology-based study].
Nan Fang Yi Ke Da Xue Xue Bao
; 39(2): 227-234, 2019 02 28.
Article
em Zh
| MEDLINE
| ID: mdl-30890513
ABSTRACT
OBJECTIVE:
To identify the main active components in Shenbing decoction â ¢ and their targets and explore the mechanism by which Shenbing decoction â ¢ alleviates proteinuria in chronic kidney disease (CKD) based on network pharmacology.METHODS:
The active components of Shenbing decoction â ¢ and their potential targets, along with the oral bioavailability and drug-like properties of each component were searched in the TCMSP database. The proteinuria-related targets were searched in the GeneCards database. The active component-target network was constructed using Cytoscape software, and the acquired information of the targets from ClueGO was used for enrichment analysis of the gene pathways.RESULTS:
A total of 102 active components were identified from Shenbing decoction â ¢. These active components acted on 126 targets, among which 69 were related to proteinuria. Enrichment analysis revealed fluid shear stress- and atherosclerosisrelated pathways as the highly significant pathways in proteinuria associated with CKD.CONCLUSIONS:
We preliminarily validated the prescription of Shenbing decoction â ¢ and obtained scientific evidence that supported its use for treatment of proteinuria in CKD. The findings in this study provide a theoretical basis for further study of the mechanism of Shenbing decoction â ¢ in the treatment of proteinuria in CKD.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Proteinúria
/
Medicamentos de Ervas Chinesas
/
Insuficiência Renal Crônica
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China