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The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells.
Kaschula, Catherine H; Tuveri, Rosanna; Ngarande, Ellen; Dzobo, Kevin; Barnett, Christopher; Kusza, Daniel A; Graham, Lisa M; Katz, Arieh A; Rafudeen, Mohamed Suhail; Parker, M Iqbal; Hunter, Roger; Schäfer, Georgia.
Afiliação
  • Kaschula CH; Department of Chemistry and Polymer Science, Stellenbosch University, Stellenbosch, 7600, South Africa. kaschula@sun.ac.za.
  • Tuveri R; Department of Biomedical Science, University of Cagliari, 09042, Monserrato, Italy.
  • Ngarande E; Department of Integrative Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
  • Dzobo K; Department of Integrative Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
  • Barnett C; International Centre for Genetic Engineering and Biotechnology (ICGEB), UCT Medical Campus, Anzio Rd, Observatory, Cape Town, 7925, South Africa.
  • Kusza DA; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa.
  • Graham LM; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa.
  • Katz AA; Department of Integrative Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
  • Rafudeen MS; Department of Integrative Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
  • Parker MI; Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa.
  • Hunter R; Department of Integrative Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
  • Schäfer G; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa.
BMC Cancer ; 19(1): 248, 2019 Mar 20.
Article em En | MEDLINE | ID: mdl-30894168
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vimentina / Movimento Celular / Dissulfetos / Alho / Neoplasias Idioma: En Revista: BMC Cancer Ano de publicação: 2019 Tipo de documento: Article País de afiliação: África do Sul
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vimentina / Movimento Celular / Dissulfetos / Alho / Neoplasias Idioma: En Revista: BMC Cancer Ano de publicação: 2019 Tipo de documento: Article País de afiliação: África do Sul