Aloin Reduces HMGB1-Mediated Septic Responses and Improves Survival in Septic Mice by Activation of the SIRT1 and PI3K/Nrf2/HO-1 Signaling Axis.

Yang, Sumin; Lee, Wonhwa; Lee, Bong-Seon; Lee, Changhun; Park, Eui Kyun; Ku, Sae-Kwang; Bae, Jong-Sup

Yang, Sumin; Lee, Wonhwa; Lee, Bong-Seon; Lee, Changhun; Park, Eui Kyun; Ku, Sae-Kwang; Bae, Jong-Sup.

Afiliação

Yang S; * College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.
Lee W; * College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.
Lee BS; * College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.
Lee C; * College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.
Park EK; Department of Pathology and Regenerative Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
Ku SK; Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea.
Bae JS; * College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.

Am J Chin Med ; 47(3): 613-633, 2019.

Article em En | MEDLINE | ID: mdl-30966773

Assuntos

Emodina/análogos & derivados; Proteína HMGB1/metabolismo; Heme Oxigenase-1/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Sepse/tratamento farmacológico; Sepse/etiologia; Transdução de Sinais/efeitos dos fármacos; Sirtuína 1/metabolismo; Aloe/química; Animais; Modelos Animais de Doenças; Emodina/administração & dosagem; Emodina/farmacologia; Proteína HMGB1/antagonistas & inibidores; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Masculino; Camundongos Endogâmicos C57BL; Fitoterapia; Sepse/genética; Sepse/metabolismo

Palavras-chave

Aloin; HMGB1; Heme Oxygenase; Nrf2; Sepsis

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Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas / Plantas_medicinales Assunto principal: Transdução de Sinais / Emodina / Sepse / Fosfatidilinositol 3-Quinases / Proteína HMGB1 / Heme Oxigenase-1 / Fator 2 Relacionado a NF-E2 / Sirtuína 1 Tipo de estudo: Prognostic_studies Idioma: En Revista: Am J Chin Med Ano de publicação: 2019 Tipo de documento: Article

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