Turnover of central biogenic amines in one-kidney, one-clip renal hypertensive rats.
Neurosci Lett
; 75(2): 223-8, 1987 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-3106860
ABSTRACT
Turnover rates, as estimated from the accumulation of the intermediates, 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition, were used to investigate the relationship between central catecholaminergic and serotonergic neurons and the development of hypertension in the one-kidney, one-clip renal hypertensive rats. Results indicated that at one week following clipping, 5-HTP accumulation was decreased in the posterior hypothalamus. At 5 weeks no changes were observed. At 20 weeks higher accumulations of both DOPA and 5-HTP were observed in the medulla oblongata while in the anterior hypothalamus DOPA accumulation was increased.
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Base de dados:
MEDLINE
Assunto principal:
Química Encefálica
/
Di-Hidroxifenilalanina
/
5-Hidroxitriptofano
/
Hipertensão Renal
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1987
Tipo de documento:
Article