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Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001.
Jiang, Lin; Pu, Hong; Qin, Xiangjing; Liu, Jianxin; Wen, Zhongqing; Huang, Yimin; Xiang, Jingxi; Xiang, Yunxi; Ju, Jianhua; Duan, Yanwen; Huang, Yong.
Afiliação
  • Jiang L; Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan, China.
  • Pu H; Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan, China.
  • Qin X; School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, Hunan, China.
  • Liu J; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
  • Wen Z; School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, Hunan, China.
  • Huang Y; Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan, China.
  • Xiang J; School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, Hunan, China.
  • Xiang Y; Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan, China.
  • Ju J; School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, Hunan, China.
  • Duan Y; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
  • Huang Y; Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan, China.
Nat Prod Res ; 35(1): 144-151, 2021 Jan.
Article em En | MEDLINE | ID: mdl-31135217
ABSTRACT
Two new natural diols, (2S, 3S, 4S)-4-methyl-1-phenylhexane-2,3-diol (1) and (2S, 3S)-4-methyl-1-phenylpentane-2,3-diol (2), together with five known compounds, xenocyloins B-D (3-5), lumichrome (6) and thymidine (7) were isolated from Streptomyces sp. CB09001. The absolute configurations of 1 and 2 were established by crystallographic structure analysis. The anti-inflammatory effects of 1-7 were also investigated in RAW246.7 murine macrophage cells stimulated by lipopolysaccharide. The indole derivative xenocyloin B (3) significantly inhibited inducible nitric oxide synthase expression in RAW264.7 cells and could be a potential anti-inflammatory drug lead.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Anti-Inflamatórios não Esteroides Idioma: En Revista: Nat Prod Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Anti-Inflamatórios não Esteroides Idioma: En Revista: Nat Prod Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China