Phenolic constituents with neuroprotective activities from Hypericum wightianum.
Phytochemistry
; 165: 112049, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31229788
ABSTRACT
Five undescribed phenolic compounds, inclusing a depsidone derivative, hyperwightin A, a flavone derivative, hyperwightin B, and three benzophenone glycosides, hyperwightins C-E, along with four known ones were isolated from the 95% EtOH extract of the whole plants of Hypericum wightianum. Structures of the obtained compounds were elucidated by spectroscopic analyses. The protective effects of the isolates against corticosterone-induced PC12â¯cell injury were assessed. Hyperwightin E, petiolin G and hyperxanthone exhibited noticeable neuroprotection at 10⯵M.
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MEDLINE
Assunto principal:
Fenóis
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Fármacos Neuroprotetores
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Hypericum
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Compostos Fitoquímicos
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Neuroproteção
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2019
Tipo de documento:
Article