Heterochelates of metals as an effective anti - Urease agents couple with their docking studies.
Pak J Pharm Sci
; 32(3 (Supplementary)): 1179-1183, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-31303588
ABSTRACT
The current article discusses the activities of several synthesized metal heterochelates in in-vitro as anti-ulcer agents followed by their docking study. For this purpose, two important ligands like 8-hydroxyquinoline and DL-methionine were used in synthesis of heterochelates of metal including Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II), Cd (II) and Pb (II). It was observed that these complexes showed excellent urease inhibition activities in which thiourea was the standard having IC50 value 21.6 ± 0.12µM. The Cu (II) complex showed potent inhibitory activity (22.6 ± 0.72 µM) when compared with the standard thiourea (21.6±0.12µM) among the nine synthesized complexes while Mn (II), Fe (III), Cd (II) and Pb (II) also showed better inhibitory activities. The urease inhibitory activities of hetercochelates also tested and validated by docking analysis.
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Base de dados:
MEDLINE
Assunto principal:
Urease
/
Quelantes
/
Inibidores Enzimáticos
Idioma:
En
Revista:
Pak J Pharm Sci
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Paquistão