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An effective drug sensitizing agent increases gefitinib treatment by down regulating PI3K/Akt/mTOR pathway and up regulating autophagy in non-small cell lung cancer.
Zhang, Jue; Qu, Zhipeng; Yao, Hong; Sun, Lingling; Harata-Lee, Yuka; Cui, Jian; Aung, Thazin Nwe; Liu, Xiaomin; You, Rongli; Wang, Wei; Hai, Lina; Adelson, David L; Lin, Lizhu.
Afiliação
  • Zhang J; First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, PR China.
  • Qu Z; Department of Genetics and Evolution, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
  • Yao H; Foshan hospital of TCM, Guangzhou University of Chinese Medicine, Foshan, Guangdong Province, PR China.
  • Sun L; First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, PR China.
  • Harata-Lee Y; Department of Genetics and Evolution, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
  • Cui J; Department of Genetics and Evolution, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
  • Aung TN; Department of Genetics and Evolution, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
  • Liu X; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, PR China.
  • You R; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, PR China.
  • Wang W; Department of Genetics and Evolution, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
  • Hai L; Zhendong Pharmaceutical Research Institute Co., Ltd., Beijing, PR China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, PR China.
  • Adelson DL; Department of Genetics and Evolution, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia. Electronic address: david.adelson@adelaide.edu.au.
  • Lin L; First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, PR China. Electronic address: linlizhu@gzucm.edu.cn.
Biomed Pharmacother ; 118: 109169, 2019 Oct.
Article em En | MEDLINE | ID: mdl-31310954
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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Autofagia / Medicamentos de Ervas Chinesas / Protocolos de Quimioterapia Combinada Antineoplásica / Resistencia a Medicamentos Antineoplásicos / Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR / Gefitinibe Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Autofagia / Medicamentos de Ervas Chinesas / Protocolos de Quimioterapia Combinada Antineoplásica / Resistencia a Medicamentos Antineoplásicos / Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR / Gefitinibe Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2019 Tipo de documento: Article